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Christoph Driessen Selected Research

Nelfinavir (Viracept)

1/2021Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma.
11/2018Promising activity of nelfinavir-bortezomib-dexamethasone in proteasome inhibitor-refractory multiple myeloma.
1/2018Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir.
3/2016Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08).
3/2014Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations.

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Christoph Driessen Research Topics

Disease

35Multiple Myeloma
01/2022 - 04/2007
19Neoplasms (Cancer)
01/2022 - 02/2008
6Multiple Sclerosis
01/2009 - 11/2002
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 01/2019
3Hematologic Neoplasms (Hematological Malignancy)
01/2022 - 03/2016
3Infections
01/2021 - 04/2007
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2022 - 03/2014
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2022 - 10/2021
2Breast Neoplasms (Breast Cancer)
01/2019 - 12/2007
2Autoimmune Diseases (Autoimmune Disease)
01/2019 - 08/2003
2Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2016 - 08/2015
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
05/2015 - 07/2014
2Hodgkin Disease (Hodgkin's Disease)
01/2008 - 01/2003
1Plasma Cell Leukemia
01/2022
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2022
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
10/2021
1Polycythemia Vera
10/2021
1Lung Neoplasms (Lung Cancer)
01/2021
1Residual Neoplasm
06/2020
1Plasmacytoma
06/2020
1Rheumatoid Arthritis
01/2020
1Psoriatic Arthritis
01/2020
1Ankylosing Spondylitis
01/2020
1Hepatocellular Carcinoma (Hepatoma)
04/2019
1Pruritus (Itching)
01/2019
1Colitis
01/2019
1Melanoma (Melanoma, Malignant)
01/2019
1Extranodal NK-T-Cell Lymphoma
10/2018
1Renal Cell Carcinoma (Grawitz Tumor)
01/2018
1Alcoholism (Alcohol Abuse)
12/2017
1Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
01/2016
1B-Cell Lymphoma (Lymphoma, B Cell)
08/2015

Drug/Important Bio-Agent (IBA)

19Proteasome InhibitorsIBA
01/2022 - 02/2008
13Bortezomib (Velcade)FDA Link
10/2021 - 07/2008
11Proteasome Endopeptidase Complex (Proteasome)IBA
01/2022 - 02/2008
6Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2016
5Pharmaceutical PreparationsIBA
10/2021 - 03/2014
5Nelfinavir (Viracept)FDA Link
01/2021 - 03/2014
5HIV Protease InhibitorsIBA
01/2021 - 07/2008
5Myelin Basic ProteinIBA
01/2009 - 11/2002
5AutoantigensIBA
01/2009 - 11/2002
4carfilzomibIBA
01/2021 - 08/2015
4Peptide Hydrolases (Proteases)FDA Link
10/2008 - 05/2003
3Lenalidomide (CC 5013)FDA Link
11/2021 - 03/2017
3ixazomibIBA
10/2021 - 10/2018
3AntigensIBA
01/2021 - 04/2007
3Immune Checkpoint InhibitorsIBA
01/2021 - 04/2019
3Dexamethasone (Maxidex)FDA LinkGeneric
06/2020 - 03/2017
3invariant chain (Ii-Key)IBA
01/2020 - 05/2003
3Monoclonal AntibodiesIBA
04/2019 - 01/2003
3Rituximab (Mabthera)FDA Link
08/2015 - 01/2003
2Peptides (Polypeptides)IBA
07/2021 - 01/2020
2EnzymesIBA
01/2020 - 12/2007
2Phosphotransferases (Kinase)IBA
11/2019 - 04/2019
2NivolumabIBA
07/2019 - 04/2019
2Messenger RNA (mRNA)IBA
02/2019 - 05/2003
2LopinavirFDA Link
01/2018 - 03/2014
2ibrutinibIBA
08/2015 - 05/2015
2Agammaglobulinaemia Tyrosine KinaseIBA
08/2015 - 05/2015
2Ritonavir (Norvir)FDA Link
03/2014 - 07/2008
2CathepsinsIBA
05/2007 - 08/2003
1ProteomeIBA
01/2022
1VaccinesIBA
12/2021
1Hydroxyurea (Hydrea)FDA LinkGeneric
10/2021
1Interferon-alpha (Interferon Alfa)IBA
10/2021
1InterferonsIBA
10/2021
1melflufenIBA
07/2021
1Membrane LipidsIBA
01/2021
1LipidsIBA
01/2021
1EpitopesIBA
01/2021
1Melphalan (Alkeran)FDA LinkGeneric
06/2020
1Prednisone (Sone)FDA LinkGeneric
06/2020
1Anti-Bacterial Agents (Antibiotics)IBA
01/2020
1AutoantibodiesIBA
01/2020
1pembrolizumabIBA
07/2019
1regorafenibIBA
04/2019
1Sorafenib (BAY 43-9006)FDA Link
04/2019
13' Untranslated Regions (3' UTR)IBA
02/2019
1MicroRNAs (MicroRNA)IBA
02/2019
1SphingomyelinsIBA
01/2019
1HLA-DRB1 Chains (HLA DRB1)IBA
01/2019
1HLA-DQB1 antigen (HLA DQB1)IBA
01/2019
1daratumumabIBA
10/2018
1CopperIBA
12/2017
1Biomarkers (Surrogate Marker)IBA
12/2017
1Disulfiram (Antabuse)FDA Link
12/2017
1Ditiocarb (Sodium Diethyldithiocarbamate)FDA Link
12/2017
1ATPases Associated with Diverse Cellular ActivitiesIBA
11/2017
1UbiquitinIBA
11/2017
1CB-5083IBA
11/2017
1Bendamustine HydrochlorideFDA Link
03/2017
1I-kappa B Proteins (I kappa B)IBA
08/2015

Therapy/Procedure

16Therapeutics
10/2021 - 10/2006
3Immunotherapy
07/2019 - 04/2007
1Drug Therapy (Chemotherapy)
06/2020
1Stem Cell Transplantation
06/2020
1Surgical Instruments (Clip)
01/2020
1Polypharmacy
01/2019
1Palliative Care (Palliative Therapy)
01/2019
1Radiotherapy
11/2018